An advanced approach, backed by hundreds of clinical studies with low false positive rates

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How we use MRI for major disease & cancer detection

Our unique approach to whole body MRI follows decades of clinical research into its use in cancer and major disease detection.

MRI stands for Magnetic Resonance Imaging. MRI scanners generate detailed images of the entire body by manipulating magnetic fields and radio waves.

Unlike CT or X-rays, an MRI scan is a safe, non-invasive test that does not use radiation. This means that a MRI whole body examination can be performed as frequently as appropriate based on the individual risk factors of your patients.

Most doctors know MRI as a brilliant, sensitive anatomical imaging device. It can see anatomical features inside the body with greater detail and precision.

But with precision came a problem - we all have unique peculiarities that present in our bodies that are completely benign but appeared on such scans. With no functional information about what was being imaged, this raised the legitimate fear of false positives. As a result the medical profession has been reluctant to embrace MRI as a way to screen for medical problems in the absence of symptoms.

But in recent years advantages in MRI hardware and software has made available a new range of functional imaging approaches that, together with anatomical images, can tell a lot about the function of imaged tissue. Using a combination of such imaging approaches it is far easier to tell apart, for example, solid tumor masses from cysts or abscesses or to image in detail the arteries in the brain to look for aneurysms.

How the Prenuvo scan compares to other scan approaches?

Traditional screening
physical exams with mammograms, prostate exams, etc
Around 30% of cancers by incidence for men and approximately 40% of cancers for women.
$400/year for women,
$300/year for men
Existing screening tests only cover a minority of cancers.
General screening tests can have poor sensitivity/specificity with many false positives.
Time consuming, multiple visits.
Whole body CT scan
Around 60% of cancers by incidence across men and women.
$600-1200 per scan
Patient receives radiation dose, increasing cancer risk. Not recommended for periodic screening.
Poor sensitivity and specificity.
Often requires administration of contrast.
Whole-body PET/CT scan
Around 55% of cancers by incidence across men and women.
$2000-3000 per scan
No real whole body approach. Different tracers tend to be used for different cancers and conditions.
Tracers are radioactive and thus not recommended for periodic screening.
Typically coupled with CT which is also radiating.
Close to 100% of cancers, with leukemia being the primary exclusion.
$1000-2500 per scan
Non radiating, can be performed as frequently as needed.
Very good sensitivity and specificity particularly with a combination of MRI screening protocols.
No injections or contrast agents.

How the Prenuvo scan performs for particular conditions compared to other approaches?

While the Prenuvo whole body scan is truly revolutionary, this doesn't mean that it is not backed by solid research. More than 300 clinical studies go into the scans and techniques that we use to image your body. In this section you can read more about how our approach compares for various different conditions.

Click on a condition to learn more.

Other
CT
PET/CT
Prenuvo

Typical symptoms

Early symptoms of lung cancer such as a persistent cough or a shortness of breath are more likely than not to be confounded with benign conditions. Without effective routine screening it is traditionally diagnosed late.

Typical stage at detection (%)

Typical survival rate (%)

What the research shows

For nodules that ranged from 6-9mm, detection with 86.4% sensitivity & 92.3% specificity. For nodules ≥10mm detection with 97% sensitivity and 96% specificity [21696559]
PET or PET/CT scan
Focal pulmonary lesions of any size were detected with 96.8% sensitivity and 77.8% specificity. [22054883]
CT scan
For lung cancer of any size, detection with 88.9% sensitivity and 92.6% specificity. [18475292]
Other modalities
Using chest x-ray, for lung cancer of any size detection with 78.3% sensitivity and 97.0% specificity.

Typical symptoms

Breast cancer enjoys high levels of awareness and well established screening appaches. Many cancers are also detected early through self-examination. Patients with a genetic suceptibility for early onset breast cancer and with dense breasts are most likely to be diagnosed late.

Typical stage at detection (%)

Typical survival rate (%)

What the research shows

One study found detection with 98.7% sensitivity and 65.8% specificity [29644993]. DWI MRI significantly outperforms other modalities in patients with dense breast tissue. At comparable specificity, DWI achieves higher sensitivity than mammogram.
PET or PET/CT scan
No research that is effective for breast cancer screening.
CT scan
No research that is effective for breast cancer screening.
Other modalities
Using mammogram, for breast cancer of any size, detection with 69% sensitivity and 94% specificity. [3523590]

Typical symptoms

Prostate cancer is typically diagnosed via a manual examination for hardness (which not all prostate cancers exhibit) and high PSA levels. Because existing screening methods suffer low sensitivity, prostate cancer is rarely diagnosed at Stage I.

Typical stage at detection (%)

Typical survival rate (%)

What the research shows

For prostate cancer of all sizes, one metastudy analysed all previous studies and found detection with 69% sensitivity and 89% specificity. [22997374]
PET or PET/CT scan
No research that is effective for breast cancer screening.
CT scan
No research that is effective for breast cancer screening.
Other modalities
Using a PSA test at the recommended cutoff of 4.0 ng/mL for cancers of all size, detection with 21% sensitivity and 91% specificity. [23730101]

Typical symptoms

The most common symptom is rectal bleeding but most people do not examine their stool routinely. Other symptoms such as abdominal pain, difficulties emptying the bowel and unexplained weigh loss are all commonly confused with benign conditions. As a result, diagnosis is typically quite late.

Typical stage at detection (%)

Typical survival rate (%)

What the research shows

For polyps ≥6 mm, detection with 85.7% sensitivity, 84.2% specificity [22898697]. For colon cancer of all sizes, one metastudy analysed all previous studies and found detection with 95% sensitivity and 93% specificity. [26770325]
PET or PET/CT scan
No research that is effective for breast cancer screening.
CT scan
For polps ≥6 mm, detection with 44% sensitivity, 93.4% specificity. For polps ≥10 mm, detection with 76.9% sensitivity and 89.0% specificity. [29174927]
Other modalities
Newer colon capsule endoscopy polyp detection with 93% sensitivity, 69% specificity [29166546]. Optical colonoscopy poplp detection >9mm with 87% sensitivity. [29166546]

Typical symptoms

Thyroid cancer is typically diagnosed early in normal patients, simply because it manifests as an unexplained lump or pain in the neck.

Typical stage at detection (%)

Typical survival rate (%)

What the research shows

For distinguishing benign from malignant lesions with 97% sensitivity and 98% specificity [22226435]
PET or PET/CT scan
For identifying medullary thyroid carcinoma recurrence detection with 62.8% sensitivity and 34.2% specificity. [29594049]
CT scan
No research that is effective for thyroid cancer detection.
Other modalities
Using conventional imaging, for identifying medullary thyroid carcinoma recurrence detection with 67.4% sensitivity and 67.1% specificity. [29594049]

Typical symptoms

Signs and symptoms of liver cancer often do not show up until the later stages of the disease which means that without a screening approach, it is often diagnosed late.

Typical stage at detection (%)

Typical survival rate (%)

What the research shows

For identifying liver cancer of all sizes, detection with 83% sensitivity and 98% specificity. [27558976]
PET or PET/CT scan
For identifying liver cancer metastates from earlier colon cancer, detection with 72.0% sensitivity and 72.1% specificity. [29736846]
CT scan
Liver cancer detection with 81.2% sensitivity and 85.5% specificity. [29740488]
Other modalities
Using contrast enhanced ultrasound, liver cancer detection with 76.8% sensitivity and 78.9% specificity. [29740488]

Typical symptoms

Early pancreatic cancers often do not cause any signs or symptoms. By the time they do cause symptoms, they have often already spread outside the pancreas. Better screening is needed improve outcomes.

Typical stage at detection (%)

Typical survival rate (%)

What the research shows

For detection of pancreatic adenocarcinoma using conventional MRI, 93% sensitivity and 89% specificity. [28624015] A study investingating DWI, detected 20mm+ tumors with 95.7% sensitivity and 100% specificity. [28784320]
PET or PET/CT scan
For detection of pancreatic adenocarcinoma, 89% sensitivity and 70% specificity. [28624015]
CT scan
For detection of pancreatic adenocarcinoma, 90% sensitivity and 87% specificity. [28624015]

Typical symptoms

Early stage bladder cancer often manifests with blood in the urine, but this can disappear for weeks at a time and is often confused with other benign conditions.

Typical stage at detection (%)

Typical survival rate (%)

What the research shows

For diagnosing malignant bladder wall pathologies, detection with 94.5% sensitivity and 87.5% specificity [29732204]
PET or PET/CT scan
No research that is effective for bladder cancer detection.
CT scan
For all bladder cancers, detection with 86.4% sensitvity and 95% specificity [26642306]
Other modalities
Traditional cytology detection with 34% sensitivity and 99% specificity. [12559279] Urine detection of nuclear mitotic apparatus protein as marker for bladder cancer, detection with 47–100% sensitivity and 60–90% specificity [29354490]

Typical symptoms

Early stage cancer is usually asymptomatic until it extends to the nearest anatomic structures, causing pain, dyspareunia, discharge or abnormal bleeding.

Typical stage at detection (%)

Typical survival rate (%)

What the research shows

For diagnosing uterine and cervix cancer, conventional MRI detection with 73.9% sensitivity and 89.5% specificity. Adding DWI increased detection to 94.7% sensitivity and 66.7% specificity [26162579]
PET or PET/CT scan
For diagnosing recurrence of cervical cancer, detection with 82% sensitivity and 95% specificity [24904653]
CT scan
For diagnosing recurrence of cervical cancer, detection with 50% sensitivity and 92% specificity [24904653]
Other modalities
Using a PAP smear, detection with 57% sensitivity and 76% specificity.[26655816]

Typical symptoms

Early stage cancer is usually asymptomatic until it extends to the nearest anatomic structures, causing pain, dyspareunia, discharge or abnormal bleeding.

Typical stage at detection (%)

Typical survival rate (%)

What the research shows

For diagnosing uterine and cervix cancer, conventional MRI detection with 73.9% sensitivity and 89.5% specificity. Adding DWI increased detection to 94.7% sensitivity and 66.7% specificity [26162579]
PET or PET/CT scan
For diagnosing recurrence of cervical cancer, detection with 82% sensitivity and 95% specificity [24904653]
CT scan
For diagnosing recurrence of cervical cancer, detection with 50% sensitivity and 92% specificity [24904653]
Other modalities
Using a PAP smear, detection with 57% sensitivity and 76% specificity.[26655816]

Typical symptoms

Ovarian cancer is usually asymptomatic in early stages, manifesting as bloating or abdominal discomfort that is confounded with routine conditions. Without effective screening it is typically diagnosed late with poor outcomes.

Typical stage at detection (%)

Typical survival rate (%)

What the research shows

For diagnosing recurrence ovarian cancer, detection with 98% sensitivity. [27585490]
PET or PET/CT scan
For diagnosing recurrence ovarian cancer, detection with 100% sensitivity. [29702969]
CT scan
For diagnosing recurrence ovarian cancer, detection with 83% sensitivity. [27585490]
Other modalities
No reliable and widespread screening tests exist. Transvaginal ultrasound is sometimes used.

Typical symptoms

Most esophageal cancers do not cause symptoms until they have reached an advanced stage, when they are harder to treat. Screening for this can significantly improve outcomes.

Typical stage at detection (%)

Typical survival rate (%)

What the research shows

For identifying esophageal cancers of all sizes, detection with 67% sensitivity and 92% specificity. [27767330]
PET or PET/CT scan
No research found showing that is effective for esophageal cancer detection.
CT scan
For identifying esophageal cancers of all sizes, detection with 83% sensitivity and 75% specificity. [27767330]
Other modalities
Using endoscopic ultrasonography, for identifying esophageal cancers of all sizes, detection with 100% sensitivity and 67% specificity. [27767330]

Typical symptoms

Early kidney cancers do not usually cause any signs or symptoms and when they do they are frequently confused with more common and benign conditions.

Typical stage at detection (%)

Typical survival rate (%)

What the research shows

For differentiating benign features from malignant renal cell carcinoma, detection with 91% sensitivity and 89% specificity. [29230706]
PET or PET/CT scan
In the diagnosis of RCC, detection with 90% sensitivity and 60% specificity. [26099672]
CT scan
In the diagnosis of RCC, detection with 90% sensitivity [28126214]
Other modalities
With contrast enhanced ultrasound for detecting small renal masses, detection with 86.8% sensitivity and 63.6% specificity. [25237460]

Typical symptoms

Laryngeal cancers that form on the vocal cords often cause hoarseness or a change in the voice. This can lead to them being found at a very early stage. For cancers that don’t start on the vocal cords, hoarseness occurs only after these cancers reach a later stage.

Typical stage at detection (%)

Typical survival rate (%)

What the research shows

For distinguishing laryngeal carcinomas from precancerous lesions, detection with 81.8% sensitivity and 64.7% specificity. [23874693]
PET or PET/CT scan
No research found showing that is effective for larynx cancer detection.
CT scan
No research found showing that is effective for larynx cancer detection.
Other modalities
No common screening modality exists.

Typical symptoms

Early detection of lymphoma requires paying close attention to any lumps in the neck, groin or armpits. But because they are not painful, they are typically ignored, leading to a late diagnosis.

Typical stage at detection (%)

Typical survival rate (%)

What the research shows

For assessment of residual disease after completion of therapy, at optimal b-values, detection with 100% sensitivity and 91.7% specificity. [25952024] Similar sensitivities have been found for initial diagnosis. [21862763]
PET or PET/CT scan
For initial diagnosis, detection with 97% sensitivity [21862763]
CT scan
No research found showing that is effective for lymphoma cancer detection.
Other modalities
No common screening modality exists.

Typical symptoms

Early-stage stomach cancer rarely causes symptoms and when it does it manifests as poor appetite, weigh loss and abdominal pain which are more likely to be associated with benign conditions. Without a screening approach, it is typically diagnosed very late.

Typical stage at detection (%)

Typical survival rate (%)

What the research shows

For diagnosis of stage I stomach cancer, detection with 75.0% sensitivity and 84.6% specificity. [28265229]
PET or PET/CT scan
For diagnosis of stage I stomach cancer, detection with 52% sensitivity and 88% specificity. [29137440]
CT scan
For diagnosis of stage I stomach cancer, detection with 66.7% sensitivity and 82% specificity. [28265229"]
Other modalities
No common screening modality exists.

Typical symptoms

Testicular cancer normally appears as a painless, unilateral scrotal mass. In approximately 20% of cases, the first symptom is scrotal pain. As the mass is increasingly recognizable as the tumor develops, diagnosis tends to be early.

Typical stage at detection (%)

Typical survival rate (%)

What the research shows

For differentiation of benign from malignant masses, detection of 93.3% sensitivity and 90% specificity. [26491491]
PET or PET/CT scan
For differentiation of benign from malignant masses, detection of 90.6% sensitivity and 80.9% specificity. [28668404]
CT scan
No research found showing that is effective for testicular cancer detection.
Other modalities
No common screening modality exists.

Typical symptoms

There are very few early symptoms but can include dizziness, seizures and headaches.

What the research shows

Many studies have shown that DWI is sensitive to detection of many types of brain tumors and brain metastases. [20886568]
PET or PET/CT scan
PET/CT using C-MET differentiates benign from malignant lesions with high sensitivity and specificity. [27095856]
CT scan
No research found showing that is effective for brain tumor detection.
Other modalities
No common screening modality exists.

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